The Wellspring Holistic Center was originally called the Holistic Arts Studio, and was founded in 1994 by massage therapists Anita Bondi and Jane Ely. It was located at 560 Main Street in Stroudsburg, Pennsylvania. The pair completely remodeled the historic space on the second floor of what used to be one of the Poconos premier banks (First Bank of Stroudsburg), while retaining the integrity of the interior space and honoring that vital part of Stroudburg's history.

The first of its kind in the Poconos, the Holistic Arts Studio presented what was a bold, new concept for the region, that of combining the offices of a group of healing practitioners with various forms of healing exercise and movement. Thus, the center has been home over the years to a wide variety of practitioners and teachers, including massage therapists, Reiki teachers, an acupuncturist, a group of midwives, yoga teachers, martial arts experts, ballet, modern dance, belly dancing, and many more types of classes and healing modalities. "We wanted to make a home for all those involved in the world of healing, to create a presence in the community, and to let people know about what we were doing. We also wanted a place where healers could come together so that we could share our ideas and our gifts."

In 1999, the name was changed to the Wellspring Holistic Center, directed by Nancy Olivieri, Kate Roche, and Cynthia Taylor. All three are also involved in the healing arts, and carried on the original mission of the space. In January 2006, construction began to turn the former Center into apartments.

The center relocated in January of 2006 to 554 Main Street, 2nd floor, Stroudsburg (above the Center for the Visual and Performing Arts). The center held its original vision for one year, keeping both classes and healing/treatment services in the same location.

In January of 2007, the healing/treatment services moved to an excellent new space called Wellspring East at 243 Brown Street, East Stroudsburg in an effort to connect more to the medical community. The new space still has four treatment rooms and offers over a dozen modalities. For now, all classes continue to be held at the Stroudsburg Main Street location.